Assistant Professor
Education |
| 1999 |
B.S. |
Nanjing University |
| 2002 |
M.S. |
Nanjing University |
| 2006 |
Ph.D.
|
Stanford University |
Positions Held |
|  |
| 2007 – 2008 |
Postdoctoral scholar, California Institute of Technology |
| 2007 – 2008 |
Research Associate, Howard Hughes Medical Institute |
| 2009 – present |
Assistant Professor, the Chinese University of Hong Kong |
Research Interests |
|
Bioorganic, biophysical chemistry, and chemical biology
Research interest in our laboratory lies at the interface of chemistry and biology. Current research focuses on answering the following questions:
1. How neuroactive oligopeptides perturb and modulate the neurological function of glial cells,
2. How cells (for example, cancer cells or neurons) interact with and respond to the extracellular matrix through carbohydrate-carbohydrate interaction, or carbohydrate-protein interaction. |
| Representative Publications |
| 1. |
Siegel, M*; Xia, J.*; Khosla, C
"Structure-based design of α-amido aldehyde containing gluten peptide analogues as modulators of HLA-DQ2 and transglutaminase 2"
Bioorganic and Medicinal Chemistry, 2007, 15(18), 6253-61 (* equal contribution) |
| 2. |
Xia, J*; Bergseng, E*; Siegel, M; Fleckenstein, B; Kim, CY; Sollid, LM; Khosla, C
"Cyclic and Dimeric Gluten Peptide Analogues to Inhibit DQ2-Mediated Antigen Presentation in Celiac Disease"
Bioorganic and Medicinal Chemistry, 2007, 15(20), 6565-73. (* equal contribution) |
| 3. |
Xia, J; Siegel, M; Bergseng, E; Sollid, LM; Khosla, C
"Inhibition of HLA-DQ2 mediated antigen presentation by analogues of a high affinity 33-residue peptide from a2-Gliadin"
Journal of the American Chemical Society, 2006, 128(6), 1859-67. |
| 4. |
Bergseng, E; Xia, J; Kim, CY; Khosla, C; Sollid, LM
"Main chain hydrogen bond interactions in the binding of proline rich gluten peptides to the celiac disease associated HLA-DQ2 molecule"
Journal of Biological Chemistry, 2005, 280(23), 21791-6. |
| 5. |
Xia, J; Sollid, LM; Khosla, C
"Equilibrium and kinetic analysis of the unusual binding behavior of a highly immunogenic gluten peptide to HLA-DQ2"
Biochemistry, 2005, 44(11), 4442-9. |
| 6. |
Xia, J; Shi, YB; Zhang, Y; Miao, Q; Tang, WX
"Deprotonation of zinc(II)-water and zinc(II)-alcohol and nucleophilicity of the resultant zinc(II) hydroxide and zinc(II) alkoxide in double-functionalized complexes: Theoretical studies on models for hydrolytic zinc enzymes"
Inorganic Chemistry, 2003, 42(1), 70-77. |
| 7. |
Xia, J; Xu, Y; Li, SA; Sun, WY; Yu, KB; Tang, WX
"Carboxy ester hydrolysis promoted by a Zinc(II) 2-[bis(2-aminoethyl)amino]ethanol complex: A new model for indirect activation on the serine nucleophile by Zinc(II) in Zinc enzymes"
Inorganic Chemistry, 2001, 40(10), 2394-2401. |
|
Contact |
|
Last updated : 17-Apr-2009 |
