CSci CChem FRSC
Professor
Education |
| B.Sc.
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University of Hong Kong
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| M.Sc.
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Imperial College, London
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| D.I.C.
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Imperial College, London
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| Ph.D.
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Birkbeck College, London
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| D.Sc.
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University of London (2002)
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Position Held |
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Since 1996
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Professor, Department of Chemistry, CUHK
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1993-1996
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Senior Lecturer, Department of Chemistry, CUHK
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1990-1993
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Lecturer, Department of Chemistry, CUHK
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1990-1990
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Visiting Associate Professor, University of California, Irvine
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1984-1990
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Lecturer, University of Manchester
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Research Interest |
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1. |
Total syntheses of homochiral, bioactive natural products and their analogs with pharmaceutical potential.
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2. |
Asymmetric synthesis using carbohydrates as diastereoselective auxiliaries and as enantioselective reagents.
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3. |
Syntheses and biological evaluation of pseudosugar derivatives as glycosidase inhibitors with potential for AIDS chemotherapy.
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4. |
Development of novel sugar-transition metal chemistry and its application to organic synthesis.
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Representative Publications |
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1. |
T. K. M. Shing and Y. Y. Yeung;
"Total Synthesis of (-)-Samaderine Y from (S)-(+)-Carvone",
Angew. Chem. Int. Ed., Vol. 44, pp. 7981-7984 (2005). |
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2. |
T. K. M. Shing, G.
Y. C. Leung, and T. Luk;
"Arabinose-Derived Ketones as Catalysts for Asymmetric
Epoxidation of Alkenes",
J. Org. Chem., Vol. 70, pp. 7279-7289 (2005). |
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3. |
T. K. M. Shing, C.
S. K. Kwong, A. W. C. Cheung, S. H.-L. Kok, Z. Yu, J.
Li, and C. H. K. Cheng;
"Facile, Efficient, and Enantiospecific Syntheses of
1,1’-N-linked-pseudodisaccharides as a New Class of
Glycosidase Inhibitors",
J. Am. Chem. Soc., Vol. 126, 15990-15992. (2004). |
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4. |
T. K. M. Shing, X. Y. Zhu, and Y. Y. Yeung;
"Studies
towards Simalikalactone D and Quassimarin:
Construction of an Advanced Pentacyclic Intermediate",
Chem. Eur. J.,
2003, Vol. 9, 5489-5500 (2003). |
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5. |
S.H.-L. Kok, C.C. Lee,
T. K. M. Shing
and T.Y. Li;
"A New Synthesis of Valienamine",
J. Org. Chem. , Vol. 66, pp. 7184-7190
(2001). |
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6. |
T.K.M. Shing
and Qi. Jiang;
"Total Synthesis of (+)-Quassin",
J. Org. Chem. , Vol. 65, pp. 7059-7069
(2000). |
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7. |
T. K. M. Shing
, and V. W.-F. Tai;
"Facile and Enantiospecific Syntheses of Goniotriol
Analogues",
J. Org. Chem., Vol. 64, pp. 2140 (1999). |
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8. |
T. K. M. Shing
, T. Y. Li, and S. H.-L. Kok;
"Enantiospecific Syntheses of Valienamine and
2-epi-Valienamine",
J. Org. Chem., Vol. 64, pp. 1941 (1999). |
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9. |
T. K. M. Shing
, Y.-L. Zhong, T. C. W. Mak, R.-J. Wang and
F. Xue;
"Acyclic Stereodifferentiation: Selective Construction
of Tetrahydropyran/Oxepane via Intramolecular
Nitrone-Alkene Cycloaddition of Acyclic 3-O-Allylmonosaccharides",
J. Org. Chem., Vol. 63, pp. 414 (1998).
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10. |
T.K.M. Shing and
E.K.W. Tam;
"Enantiospecific Syntheses of (+)-crotepoxide, (+)-boesenoxide,
(+)-b-senepoxide, (+)-pipoxide
acetate, (-)-iso-crotepoxide, (-)-senepoxide,
and (-)-tingtanoxide from (–)-quinic Acid",
J. Org. Chem., Vol. 63, pp. 1547 (1998).
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Professional Activities |
Chartered Chemist
Fellow of the Royal Society of Chemistry
Member, American Chemical Socity
Member, Hong Kong Institution of Science |
Contact |
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