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BSc, PhD
Research Assistant Professor
Education Background |
| 2001–2005 |
Ph.D. in Chemistry
The Chinese University of Hong Kong |
| 1998–2001 |
B.Sc. (Hons.) in Chemistry, First Class
Shaw College, The Chinese University of Hong Kong |
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Positions Held |
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Since 2009 |
Research Assistant Professor, Department of Chemistry,
The Chinese University of Hong Kong |
Jan 2007 –
Dec 2008 |
Postdoctoral Fellow, Division of Biophysics and Bioimaging,
Ontario Cancer Institute, Canada |
Sep 2005 –
Jan 2007 |
Postdoctoral Fellow, Department of Chemistry,
The Chinese University of Hong Kong |
Research Interests |
| (1) |
Development of peptide-conjugated fluorescence probes for specific in vivo cancer imaging |
| (2) |
Exploration of third-generation photosensitizers for photodynamic therapy |
Representative Publications |
| (1) |
“Photodynamic Molecular Beacon Triggered by Fibroblast Activation Protein on Cancer-Associated Fibroblasts for Diagnosis and Treatment of Epithelial Cancers”
P.-C. Lo, J. Chen, K. Stefflova, M. S. Warren, R. Navab, B. Bandarchi, S. Mullins, M. Tsao, J. D. Cheng and G. Zheng
J. Med. Chem., in press. |
| (2) |
“Synthesis and in vitro Photodynamic Activities of Di-a-Substituted Zinc(II) Phthalocyanine Derivatives”
J.-Y. Liu, P.-C. Lo, X.-J. Jiang, W.-P. Fong and D. K. P. Ng
Dalton Trans., in press. |
| (3) |
“A Tumor mRNA-Triggered Photodynamic Molecular Beacon Based on Oligonucleotide Hairpin Control of Singlet Oxygen Production”
J. Chen, J. F. Lovell, P.-C. Lo, K. Stefflova, M. Niedre, B. C. Wilson and G. Zheng
Photochem. Photobiol. Sci., 7, 775-781 (2008). |
| (4) |
“Effects of Peripheral Chloro Substitution on the Photophysical Properties and in vitro Photodynamic Activities of Galactose-Conjugated Silicon(IV) Phthalocyanines”
P.-C. Lo, W.-P. Fong and D. K. P. Ng
ChemMedChem, 3, 1110-1117 (2008). |
| (5) |
“Photodynamic Activity of BAM-SiPc, an Unsymmetrical Bisamino Silicon(IV) Phthalocyanine, in Tumour-Bearing Nude Mice”
S. C. H. Leung, P.-C. Lo, D. K. P. Ng, W.-K. Liu, K.-P. Fung and W.-P. Fong
Br. J. Pharm., 154, 4-12 (2008). |
| (6) |
“Using the Singlet Oxygen Scavenging Property of Carotenoid in Photodynamic Molecular Beacons to Minimize Photodamage to Non-Targeted Cells”
J. Chen, M. Jarvi, P.-C. Lo, K. Stefflova, B. C. Wilson and G. Zheng
Photochem. Photobiol. Sci., 6, 1311-1317 (2007). |
| (7) |
“Synthesis and in vitro Photodynamic Activity of Mono-Substituted Amphiphilic Zinc(II) Phthalocyanines”
P.-C. Lo, B. Zhao, W. Duan, W.-P. Fong, W.-H. Ko and D. K. P. Ng
Bioorg. Med. Chem. Lett., 17, 1073-1077 (2007). |
| (8) |
“Hetero-Arrays of Porphyrins and Phthalocyanines”
P.-C. Lo, X. Leng and D. K. P. Ng
Coord. Chem. Rev., 251, 2334-2353 (2007). |
| (9) |
“Highly Photocytotoxic Glucosylated Silicon(IV) Phthalocyanines. Effects of Peripheral Chloro Substitution on the Photophysical and Photodynamic Properties”
P.-C. Lo, C. M. H. Chan, J.-Y. Liu, W.-P. Fong and D. K. P. Ng
J. Med. Chem., 50, 2100-2107 (2007). |
| (10) |
“New Amphiphilic Silicon(IV) Phthalocyanines as Efficient Photosensitizers for Photodynamic Therapy: Synthesis, Photophysical Properties, and in vitro Photodynamic Activities”
P.-C. Lo, J.-D. Huang, D. Y. Y. Cheng, E. Y. M. Chan, W.-P. Fong, W.-H. Ko and D. K. P. Ng
Chem. Eur. J., 10, 4831-4838 (2004). |
Contact |
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Office: Room 245, North Block, University Science Center |
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Laboratory: Room 106-108, Centralized Labs |
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(852) 2696 1326 |
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(852) 2603 5057 |
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pclo@cuhk.edu.hk |
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Last Updated : 14-Jan-2009 |
