Associate Professor
| Education |
| 1992 |
B.Sc. |
The Chinese University of Hong Kong |
| 1996 |
Ph.D. |
The Chinese University of Hong Kong |
Position Held |
| Since 2009 |
Associate Professor,
The Chinese University of Hong Kong |
| 2003-2009 |
Assistant Professor,
The Chinese University of Hong Kong |
| 1999-2003 |
Assistant Professor (Replacement Teacher),
The Chinese University of Hong Kong |
| 1997-1999 |
Postdoctoral Fellow,
Department of Biochemistry and Biophysics,
Oregon State University |
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| Research Interest |
| 1. |
Biophysical chemistry of nucleic acids: (i) molecular mechanism of genetic instabilities; (ii) fidelity of DNA replication; (iii) mechanistic pathways of DNA damage and repair |
| 2. |
Development of NMR methods for structure determination of nucleic acids. |
| 3. |
Application of high resolution NMR spectroscopy in biomedical analysis. |
Recent Representative Publications : |
| 1. |
Fenn, D., Chi, L.M. and Lam, S.L. (2008) Effect of hyperoxidized guanine on DNA primer-template structures: Spiroiminodihydantoin leads to strand slippage. FEBS Lett 582, 4169-4175. |
| 2. |
Chi, L.M. and Lam, S.L. (2008) Nuclear magnetic resonance investigation of primer-template models: formation of a pyrimidine bulge upon misincorporation. Biochemistry 47, 4469-4476. |
| 3. |
Yang, H., Zhan, Y., Fenn, D., Chi, L.M. and Lam, S.L. (2008) Effect of 1-methyladenine on double-helical DNA structures. FEBS Lett 582, 1629-1633. |
| 4. |
Chi, L.M. and Lam, S.L. (2007) NMR investigation of primer-template models: Structural effect of sequence downstream of a thymine template on mutagenesis in DNA replication. Biochemistry 46, 9292-9300. |
| 5. |
Lam, S.L. (2007) DSHIFT: a web server for predicting DNA chemical shifts. Nucleic Acids Res. 35, W713-717. |
| 6. |
Lam, S.L., Lai, K.F. and Chi, L.M. (2007) Proton chemical shift prediction of A.A mismatches in B-DNA duplexes. J. Magn. Reson. 187, 105-111. |
| 7. |
Chi, L.M. and Lam, S.L. (2006) NMR investigation of DNA primer-template models: Structural insights into dislocation mutagenesis in DNA replication. FEBS Lett. 580, 6496-6500. |
| 8. |
Chi, L.M. and Lam, S.L. (2005) Structural roles of CTG repeats in slippage expansion during DNA replication. Nucleic Acids Res. 33, 1604-1617. |
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Click here for a full list of publications |
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