Assistant Professor
| Education |
| 1992 |
B.Sc. |
The Chinese University of Hong Kong |
| 1996 |
Ph.D. |
The Chinese University of Hong Kong |
Position Held |
| Since 1999 |
Assistant Professor, The Chinese University of Hong Kong |
| 1997-1999 |
Postdoctoral Fellow,
Department of Biochemistry and Biophysics, Oregon State University |
|
 |
| Research Interest |
| 1. |
Biophysical chemistry of nucleic acids: (i) molecular mechanism of genetic instabilities; (ii) fidelity of DNA replication; (iii) mechanistic pathways of DNA damage and repair |
| 2. |
Development of NMR methods for structure determination of nucleic acids. |
| 3. |
Application of high resolution NMR spectroscopy in biomedical analysis. |
Recent Representative Publications : |
| 1. |
Chi, L.M. and Lam, S.L.
“NMR Investigation of Primer-Template Models: Structural Effect of Sequence downstream of a Thymine Template on Mutagenesis in DNA Replication”,
Biochemistry, Vol. 46, pp. 9292-9300 (2007). |
| 2. |
Lam, S.L.
“DSHIFT: a Web Server for Predicting DNA Chemical Shifts”,
Nucleic Acids Res. Vol. 35, Web Server Issue, pp. W713-W717 (2007). |
| 3. |
Lam, S.L., Lai, K.F. and Chi, L.M.
“Proton Chemical Shift Prediction of A.A Mismatches in B-DNA Duplexes”,
J. Magn. Reson., Vol. 187, pp. 105-111 (2007). |
| 4. |
Chi, L. M. and Lam, S. L.
“NMR Investigation of DNA Primer-Template Models: Structural Insights into Dislocation Mutagenesis in DNA Replication”,
FEBS Lett., Vol. 580, pp. 6496-6500 (2006). |
| 5. |
Chi, L.M. and Lam S.L.
“Structural Roles of CTG Repeats in Slippage Expansion during DNA Replication”,
Nucleic Acids. Res., Vol. 33, pp. 1604-1617 (2005). |
Contact |
|
Research positions are available. Please contact Prof. LAM for details. |
