Department of Chemistry, The Chinese University of Hong Kong

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Faculty

Prof. T-W. Dominic Chan

BSc(First Hons), PhD (University of Warwick, U.K.)


l Professor of Department of Chemistry, CUHK l Hong Kong Society for Mass Spectrometry (HKSMS) - Founding Member (1998) - Vice-president (1999-00) - President (2000-02, 2005-06) l Member of the Editorial Advisory Board - European Journal of Mass Spectrometry - Journal of Chinese Mass Spectrometry Society l External Assessor for Grant Applications - HK Research Grants Council - HK Baptist University - Academic Sinica, Taiwan l Peer Reviewer for Research Papers - Journal of American Society for Mass Spectrometry - European Journal of Mass Spectrometry - Rapid Communication in Mass Spectrometry - Inorganic Chemistry Communication l Member of American Society for Mass Spectrometry l Service to Hong Kong Examination Authority - Chief Examiner of the HK A-Level Chemistry Examination (1998) l Organiser of Professional Activities - Two-week Training Workshop on Mass Spectrometry and State-of-the-Art Mass Spectrometry Instruments for PRC Young Scientists (1998) - The 4^th International Uppsala Conference on Electron Capture and Dissociation Mass Spectrometry – Fundamental and Applications (2006) l Exemplary Teaching Award, Faculty of Science, The Chinese University of HK (2002)

Correspondence Address :	Department of Chemistry, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong SAR
Phone : (852) 2609-6260 FAX: (852) 2603-5057 E-mail : twdchan@cuhk.edu.hk

Research Interests

      §    Development of new mass spectrometry interfaces:
                       o    MALDI   interface for FTMS
                       o    Nanospray & nano-LC interface for FTMS

§ Experimental and theoretical investigations of the novel mass spectrometry
dissociation methods for structural analysis of proteins and DNA fragments

§ Detection and characterization of bioactive polysaccharides from herbal medicines

Research Grants/Funding
Total Amount (1994-2006: HKD 14.48 millions)

2006	Sponsorship of International Conference The Croucher Foundation	HKD100,000
2006, 2004, 2003, 2000, 1998, 1996, 1995	Earmarked Grants Research Grants Council, HKSAR	HKD4,308,500
2002	Summer Research Grants The Chinese University of HK	HKD47,000
2002	Special Equipment Grants The Chinese University of HK	HKD1,000,000
2002, 1994	Direct Grants The Chinese University of HK	HKD286,000
1997, 1995	Industrial Support Fund Department of Industry	HKD7,100,000
1997	Joint HK/UK Research Scheme British Council	HKD60,000
1997	Lee Hysan Foundation Fund	HKD300,000
1997	One-time Support Funded Projects The Chinese University of Hong Kong	HKD1,450,000
	Total Amount	HKD14.48 millions

Research Collaborations
          l University of Washington, Seattle, USA
          l Uppsala University, Sweden
          l University of Warwick, United Kingdom
          l Chinese Academy of Sciences, PRC
          l Peking University, PRC
          l Tsinghua University, PRC
          l Hong Kong University of Science & Technology, Hong Kong
          l Institute of Chinese Medicine, The Chinese University of Hong Kong
          l Faculty of Medicine, The Chinese University of Hong Kong

Publications

1. “Electron Caption Dissociation of Peptides Metalated with Alkaline Earth Metal Ions” J. Am. Mass Spectrom. 2006, 17. 757.

2. “Analyses of Stemona Alkaloids in Stemona Tuberosa by Liquid Chromatography / Tandem Mass Spectrometry, Y. Zhou, R.-W. Jaing, P.-M. Hon, Y.-T. Xu, Y.-M. Chan, T.-W. D. Chan, H.-X. Xu, L.-S. Ding, P. P.-H. But, P.-C. Shaw, Rapid Commun. Mass Spectrom., 2006, 20, 1030.

3. “Determination of molecular weight profile for a bioactive b-(1®3) polysaccharides -curdlan”, T.-W. D. Chan, P.K. Chan and K.Y. Tanf, Anal. Chim. Acta, 2006, 556,226.

4. “Facile disulfide bond cleavage in gaseous peptide and protein cations by 157-nm ultra-violet photo-dissociation”, Eva Y. M. Fung, Frank Kjeldsen, Oleg A. Silivra, T.-W. D. Chan and Roman A. Zubarev, Angew. Chem. Int. Ed., 2005, 44, 2.

5. “Experimental and theoretical investigations of the loss of amino acid side chains in electron capture dissociation of model peptides”, Y. M. E. Fung and T.-W. D. Chan, J. Am. Soc. Mass Spectrom., 2005, 16, 1523.

6. “A modified internal lock-mass method for calibration of the product ions derived from sustained off-resonance irradiation collision-induced dissociation (SORI-CID) using a Fourier transform mass spectrometer (FTMS)” L. Duan and T.-W. D. Chan, Rapid Commun. Mass Spectrom., 2004, 18, 1286.

7. “A comparative study of the collision induced dissociation and the electron capture dissociation of model peptides using ESI-FTMS” Y.M.E. Fung, L. Duan and T.-W. D. Chan, Euro. J. Mass Spectrom., 2004, 10, 449.

8. “Analysis of a bioactive b-(1®3) polysaccharide (Curdlan) by using matrix-assisted laser desorption / ionization time-of-flight mass spectrometry (MALDI-TOFMS)” T.-W.D. Chan and K. Y. Tang, Rapid Commun. Mass Spectrom., 2003, 17, 1.

9. “Accurate mass measurements for peptide and protein mixtures by using matrix-assisted laser desorption/ionization Fourier transform mass spectrometry (MALDI-FTMS)”, T.-W. D. Chan, L. Duan and T.-P. E. Sze, Anal. Chem., 2002, 74, 5282.

10. “Optimization of Experimental Parameters for Electron Capture Dissociation of Peptides in a Fourier Transform Mass Spectrometer (FTMS)”, T.-W.D. Chan and W.H.H. Ip, J. Am. Soc. Mass Spectrom., 2002, 13, 1396.

11. “A study of fast and metastable dissociations of adenine-thymine binary-based oligonucleotides by using positive-ion MALDI-TOF mass spectrometry”, T.-W. D. Chan, Y. M.E. Fung and Y. C. L. Li, J. Am. Soc. Mass Spectrom., 2002, 13, 1052.

12. "Tetrapyrrole derivatives substituted with ferrocenylethynyl moieties. Synthesis and Electrochemical studies", K-W. Poon, W. liu, P-K. Chan. Q. Yang, T-W. D. Chan, T.C.W. Mak and D.K.P. Ng, J. Org. Chem., 2001, 66, 1553.

13. "Antioxidative Glucosides from the fruits of Ligustrum lucidium",Z-D. He, P.P-H. But, T-W.D. Chan, H. Dong, H-X. Xu, C-P. Lau and H-D. Sun, Chem. Pharm. Bull, 2001, 49, 780.

14. “Sequence analysis of peptides with biological activities using electrospray-Fourier transform ion cyclotron resonance mass spectrometry”, M. He, J. Xu, T-W. D. Chan and R.L.C. Lau, Chinese Science Bulletin, 2001, 46, 1281.

15. "Effect of sample preparation methods on the analysis of dispersed polysaccharides by MALDI-TOF mass spectrometry, Rapid Commun. Mass Spectrom., 2000, 14, 1841.

16. "Differentiation of enantiomers by using matrix-assisted laser desroption / ionization (MALDI) mass spectrometry", M.P. So, T.S.M. Wan and T-W.D. Chan, Rapid Commun. Mass Spectrom., 2000, 14, 692.

17. "Differentiation and authentication of Panax ginseng, Panax quinquefolius and ginseng products by using HPLC/MS", T-W.D. Chan, P.P.H. But, S.W. Cheng, I.M.Y. Kwok, F.W. Lau and H.X. Xu, Anal. Chem., 2000, 72, 1281.

18. "Synthesis and structural characterization of highly chlorinated, brominated, iodinated, and methylated carbroane anions, H-1-CB₉X₉^-, NH₂-1-CB₉X₉^- (X = Cl, Br, I), and H-1-CB₉(CH₃)₉^-", Inorg. Chem., 2000, 39, 3582.

19. “Weakly coordinating nature of a carborane cage bearing different halogen atoms. Synthesis and structural characterization of icosahedral mixed halocarborane anions, 1-H-CB₁₁Y₅X₆^- (X, Y = Cl, Br, I)", Inorg. Chem., 2000, 39, 5851.

20. "Time-of-flight effects in matrix-assisted laser desorption / ionization Fourier transform mass spectrometry", E.T-P. Sze and T-W.D. Chan, Rapid Commun. Mass Spectrom., 1999, 13, 1.

21. "A novel non-metallized tip for electrospray mass spectrometry at nanoliter flow rate", K.W.Y. Fong and T-W.D. Chan, J. Am Mass Spectrom. Soc., 1999, 10, 72.

22. "Highly Chlorinated, brominated, and iodinated icosahedral carbonane anions: 1-H-CB₁₁X₁₁^-, 1-CH₃-CB₁₁-X₁₁^- (X = Cl, Br, I); 1-Br-CB₁₁B₁₁^-", Z. Xie, C-W. Tsang, E.T-P. Sze, Q. Yang, T-W.D Chan and T.C.W. Mak, Inorg. Chem., 1998, 37, 6444.

23. "Evaluation of ammonium salts as co-matrices for matrix-assisted laser desorption / ionization mass spectrometry of oligonucleotides", Y.C.L. Li, S-W. Cheng and T-W.D. Chan, Rapid Commun. Mass Spectrom., 1998, 12, 993.

24. "Origins of proton in the generation of ions from polymers and peptides in matrix-assisted laser desorption / ionization", C.K.L. Wong, M.P. So and T-W.D. Chan; Euro. Mass Spectrom., 1998, 4, 223.

25. "Formulation of matrix solutions for use in matrix-assisted laser desorption/ionization (MALDI) of Biomoelcules", E.T.P. Sze, G. Wang and T-W.D. Chan; J. Am Mass Spectrom. Soc., 1998, 9, 166-174.

26. "Cationization processes in matrix-assisted laser desorption/ionization mass spectrometry : Attachment of divalent and trivalent metal ions" C.K.L. Wong and T-W.D. Chan; Rapid Commun. Mass Spectrom., 1997, 11, 513-519.

27. "Fourier Transform ion cyclotron resonance studies of Lanthanide(III) porphyrin-phthalocyanine heteroleptic sandwich complexes using electrospray ionization", R.L.C. Lau, J.Jiang, D.K.P. Ng and T-W.D. Chan; J. Am Mass Spectrom. Soc., 1997, 8, 161-169.

28. "Sesquterpene lactones from Elephantopus scaber", P.P-H. But, P-M.Hon, T-W.D. Chan, T.C.W. Mak and C-T. Che; Phytochemistry, 1997, 44, 113-116.

29 "Synthesis, spectroscopic and electrochemical properties of substituted bis(phthalocyaninato)lanthanide(III) complexes", J. Jiang, R.C.W. Liu, T.C.W. Mak, T-W.D. Chan and D.K.P. Ng, Polyhedron, 1997, 16, 515-520.

30 "Synthesis and spectroscopic properties of heteroleptic sandwich-type (phthalocyaninato)(porphyrinato)lanthanide(III) complexes", J. Jiang, R.L.C. Lau, T-W.D. Chan, T.C.W. Mak and D.K.P. Ng; Inorg. Chim Acta, 1997, 255, 59-64.

31. "Mass spectra of hydrazo, azo and azoxy compound", T-W.D. Chan and S.W. Tam, in The Chemistry of Hydrazo, Azo and Azoxy Groups, vol. 2, edited by S. Patai, John Wiley, & Sons Ltd., Chichester, 1997, Chap. 4, pp. 105-135.

32. "Dendritic models of redox proteins: X-ray photoelectron spectroscopy and cyclic voltammetry studies of dendritic bis(terpyridine) iron(II) complexes", H-F Chow, Y-K. I Chan, T-W. D Chan and R.W.M. Kwok; Chem. Eur. J., 1996, 2, 133

33. "Positive-ion electrospray mass spectra for a number of polypeptides and proteins", M. He, J. Xu, T-W.D. Chan and R.L.C. Lau; Rapid Commun. Mass Spectrom., 1996, 10, 987-902.

34. "Use of ammonium halides as co-matrices for matrix-assisted laser desorption/ionization studies of oligonucleotides", S-W. Cheng and T-W.D. Chan; Rapid Commun. Mass Spectrom., 1996, 10, 907-910.

35. "Fourier transform ion cyclotron resonances studies of terpyridine-based polyether dendrimers and their iron(II) metallocomplexes by liquid secondary ion mass spectrometry", R.L.C. Lau, T-W. D. Chan, I.Y-K. Chan and H.F. Chow; Euro. Mass Spectrom., 1995, 1, 371-380.

36. "Initial velocities of positive and negative protein molecule-ions produced in matrix-assisted ultraviolet laser desorption using a liquid matrix", T-W.D. Chan, I. Thomas, A.W. Colburn and P.J. Derrick; Chem. Phys. Lett., 1994, 222, 579.

37. "Design considerations in energy resolved time-of-flight mass spectrometry", A.E. Giannakopulos, D.J. Reynolds, T-W.D. Chan, A.W. Colburn and P.J. Derrick; Int. J. Mass Spectrom. Ion Phys., 1994, 131, 67.

38. "Threshold fluences for production of positive and negative ions in matrix-assisted laser desorption / ionisation using liquid and solid matrices", P.Y. Yau, T-W. D. Chan, P.G. Cullis, A.W. Colburn and P.J. Derrick; Chem. Phys. Lett., 1993, 202, 93.

39. "Suppression of matrix-ions in ultraviolet laser desorption: Scanning electron microscopy and Raman spectroscopy of the solid sample", T-W.D. Chan, A.W. Colburn, P.J. Derrick, D.J. Derek and M. Bowden; Org. Mass Spectrom., 1992, 27, 188.

40. "Matrix-assisted laser desorption / ionization using a liquid matrix: Formation of high-mass cluster ions from proteins", T-W.D. Chan, A.W. Colburn and P.J. Derrick; Org. Mass Spectrom., 1992, 27, 53.

41. "Matrix-assisted ultraviolet laser desorption: Suppression of the matrix peaks", T-W.D. Chan, A.W. Colburn and P.J. Derrick; Org. Mass Spectrom., 1991, 26, 342.

42. "Computer-controlled activation of 25µm diameter tungsten wire for field desorption", T-W. D. Chan, A.W. Colburn and P.J. Derrick; Int. J. Mass Spectrom. and Ion Phys., 1991, 107, 491..

Contact Information

Corresponding Address

Department of Chemistry

The Chinese University of Hong Kong

Shatin, N.T., Hong Kong SAR

Phone: (852)-2609-6260

Fax: (852)-2603-5057

E-mail: twdchan@cuhk.edu.hk